Nikephoros Kantakouzenos

Nikephoros Kantakouzenos (c. 1300–after 1355) was a Byzantine aristocrat and governor, a cousin of Emperor John VI Kantakouzenos. In 1341, at the start of the civil war, Alexios Apokaukos had him imprisoned in Constantinople with other members of the family; he was freed only when John VI entered the city in March 1347.

By 1351 he held the rank of sebastokrator and governed Adrianople, defending its citadel with Matthew Kantakouzenos against John V in 1352. After John VI's fall in December 1354 he kept Adrianople for Matthew. His daughter Theodora married Alexios III of Trebizond in 1351.