Manuel Palaiologos

Manuel Palaiologos (1297–1320) was a Byzantine prince and despot, the younger son of co-emperor Michael IX Palaiologos and Rita of Armenia, and grandson of Andronikos II.

In 1320, during an affair of his elder brother Andronikos with a woman of humble birth, Manuel went to her house at night; the brother's retainers, mistaking him for a rival, killed him. His father Michael IX died of grief only days later, and the murder helped drive the rift that ignited the civil war between Andronikos II and Andronikos III.