Isabelle de Lusignan

Isabelle de Lusignan (born c. 1333) was the daughter of Guy de Lusignan, a prince of the Cypriot Lusignan dynasty, and the Byzantine noblewoman Theodora Syrgiannaina. Her father was crowned king of Armenian Cilicia as Constantine II in 1342 but was murdered at Adana in November 1344 in an anti-Latin rising, while Isabelle stayed at the Byzantine court.

In 1349 she married Manuel Kantakouzenos, son of Emperor John VI and despot of the Morea at Mystras, becoming its despoina and holding lands including Aradippou on Cyprus. She died after 1387 and was buried at Mystras.