Isaac Angelos Doukas

Isaac Angelos Doukas was a twelfth-century Byzantine nobleman and commander, a son of Constantine Angelos and of Theodora Komnene, daughter of Emperor Alexios I Komnenos. His brother Andronikos fathered Emperor Isaac II Angelos, who appointed him strategos of the theme of Cilicia.

A daughter of Isaac married Basil Vatatzes, domestikos of the West. His son Constantine Angelos Doukas became megas doux of the fleet and was blinded after a failed bid for the throne in 1193.