Eirene Komnene Kantakouzene Palaiologina Asanina

Eirene Komnene Kantakouzene Palaiologina Asanina, born Eirene Synadene, was a Byzantine aristocrat of the fourteenth century, the younger daughter of the megas konostaulos John Synadenos and Thomais Komnene Doukaina Laskarina. By about 1330 she had married Michael Komnenos Tornikes Asanes, a grandson of the Bulgarian tsar Ivan Asen III and later governor of Lesbos.

The couple appear together in a miniature in the typikon of the Bebaia Elpis convent, founded by Eirene's grandmother Theodora Synadene. Their children died young. After Michael's death, Eirene commissioned Nikephoros Gregoras to compose an epitaph in his memory.