Anna Komnene Palaiologina

Anna Komnene Palaiologina (1260–1300) was a Byzantine princess, a daughter of Emperor Michael VIII Palaiologos and Empress Theodora Vatatzaina. Michael VIII first betrothed her to Stefan Uroš II Milutin of Serbia, but when Anna arrived the Serbian king answered her rich clothes and jewels by showing the envoys a poorly dressed local woman, and the match collapsed.

In 1278 she married Demetrios Doukas Komnenos Koutroules, a son of Michael II of Epirus, who received despot rank from the emperor; Anna became despoina of Epirus. They had two sons, Andronikos and Constantine.