Anna Komnene Angelina
Anna Komnene Angelina (c. 1176–1212) was a daughter of Emperor Alexios III Angelos and Euphrosyne Doukaina Kamatera. Her first husband, the sebastokrator Isaac Komnenos Vatatzes, was captured fighting a Bulgarian revolt in 1195 and died in prison.
In late 1199 she married Theodore Laskaris, and in autumn 1203 fled with him from the Fourth Crusade to Asia Minor. When Theodore founded the Empire of Nicaea in 1205 she became its empress. She died in 1212; her daughters Irene and Maria married John III Vatatzes and Béla IV.