Irene Palaiologina of Trebizond

Irene Palaiologina (c. 1315 – after 1341) was an illegitimate daughter of the Byzantine emperor Andronikos III. In 1335 she married Emperor Basil of Trebizond, who divorced her in 1339 for a mistress also named Irene.

On 6 April 1340 she probably had Basil poisoned and seized the throne, becoming Trebizond's second reigning empress. Her position was insecure, since she was not a member of the ruling Komnenos dynasty; she sent Basil's second wife and sons to Constantinople.

Civil war followed, and rumours of a lover sparked rioting. On 17 July 1341 Anna Anachoutlou took Trebizond; Irene was deposed and sent to Constantinople.