Mirza Shah Hossein

Mirza Shah Hossein, in full Mirza Kamal al-Din Shah Hossein Isfahani (died 1523), was a Persian statesman of the early Safavid Empire and a native of Isfahan. Trained as an architect, in 1503 he became vizier to the Qizilbash governor Durmish Khan Shamlu.

After the Battle of Chaldiran in 1514, he found Shah Ismail I's favorite wife, lost in Azerbaijan, and the shah named him vakil (vicegerent) and vizier. In 1515 he protested the Portuguese conquest of Hormuz, seeking an alliance and gunners.

A close favorite of the withdrawn shah, he amassed power and in 1521 forced his old master Durmish Khan out to Herat. In April 1523 angry Qizilbash chiefs murdered him.