Guido Orsini

Guido Orsini (1305–1348), second son of Romano Orsini, count of Sovana, founded the Pitigliano line of the House of Orsini. In 1336 his father granted him Sovana, later called the county of Pitigliano after its unhealthy capital was abandoned. At the locals' call he warred on Ermanno Monaldeschi, lord of Orvieto.

He served Perugia as captain general from 1342, and in 1347 became lord and defender of Orvieto. He fled the plague and died in 1348, leaving sons Aldobrandino and Gentile.