Guido Orsini

Guido Orsini, also called Guy, was the third son of John I Orsini, count palatine of Cephalonia and Zakynthos, and Maria Komnene Doukaina, daughter of the Despot of Epirus Nikephoros I. While his elder brothers Nicholas and John II made themselves despots of Epirus in 1318–1335, Guido was constable of the Principality of Achaea, to which his family's island county owed vassalage, and is attested in documents down to 1326.

His possible son John III, called Tsaphas, bore the title of count of Leucas and in 1361 served the Serbian ruler Simeon Uroš as megas konostaulos, or grand constable. Later family genealogies give Guido the Orsini estates in Italy and date his death to 1336.